Cpcsea guidelines 2014 pdf
Subs. by G.S.R. 889(E) dated 12-12-2014 2. Ins. By G.S.R. 53(E) dated 30-1-2013 . ... and the GCP Guidelines and also for compliance as per the undertaking given in Appendix VII. Standard operating procedures are required to be documented by the investigators for the tasks performed by them. ... IJPSR (2014), Vol. 5, Issue 4 (Research Article) ... were handled in accordance with the guidelines for ... Supervision of Experiments on Animals (CPCSEA, India). Experimental Design: The data used in our evaluation consisted of data from control rats in one and four week’s studies, which were conducted between December, 2009 and July, 2012 ... out according to CPCSEA guidelines. Animals were acclimatized to the animal quarantine for one week prior to the experiment under controlled conditions of temperature (27 ± 2oC) and were housed in sterile polypropylene cages containing paddy husk as bedding material …
The ethical clearance was taken from the Institutional Animal Ethics Committee (401/CPCSEA, dated 23/03/2011), and all the experiments were carried out as per CPCSEA guidelines. Adult albino rats of either sex weighing 200-250g of Charles foster strain were divided into 5 … CPCSEA guidelines; Institutional ethics committees; Ethical consideration in research on human beings ; Working in Laboratory. Good laboratory practice; Safety and bio- and radio- hazards, disposal of biological and chemical wastes ; Accuracy of liquid transfer ; Preparation of Reagents, chemicals, buffers; General safety and precautions guidelines. So this study was carried out to verify the neuroprotective effect of vitamin B complex from morphological changes of the diabetic rat sci-atic nerve. A total number of 30 adult male albino rats were used and divided into three groups. Group I: normal vehicle control (N=10). Group II: Compendium of CPCSEA 2018, Committee for the Purpose of Control and Supervision of Experiments on Animals (CPCSEA), Ministry of Environment, Forest and Climate Change, Government of India PDF … In Indian Pharmacopoeia 2014, pyrogen testing using rabbits has been replaced by the bacterial endotoxin test in the majority of biological monographs—keeping in view international trends and, especially for vaccine monographs, validated in vitro tests such as the bacterial endotoxin test as an alternative to the pyrogen test where justified ... an animal hold area, as per CPCSEA Guidelines is required. *As per the terms of Notification published on 19.03.2014 in the Gazette of India. A.1.10 Incinerator An incinerator Plant commensurate with hospital bed strength may be provided. Alternatively any other system approved by the respective State Pollution Control Board may be provided.
Journal of Indian Academy of Oral Medicine and Radiology (JIAOMR) (ISSN: Print - 0972-1363, Online - 0975-1572), an official publication of the Indian Academy of Oral Medicine and Radiology (IAOMR), is a peer-reviewed journal published every quarter, both in the form of hard copies (print version) as well as on the web (electronic version).The journal’s full text is available online at http ... 47 th meeting of CPCSEA was held on 20 th May, 2014 under the Chairmanship of Shri Hem Pande, Additional Secretary. 6. One day Workshop on “Use of Experimental Animals in Toxicity Studies and Research” was held on 9 th June, 2014 at Pushpagiri Medical College Sciences & Research Centre, Tiruvalla – 689 101, Kerala with the support of CPCSEA. Clinical studies of Saroglitazar have also shown that it is a safe glitazar class compound (Jani et al. 2014; Pai et al. 2014). In conclusion, Saroglitazar is a nonfibrate, non-TZD next generation PPAR agonist that has shown beneficial effects on lipids and glucose in various preclinical and clinical studies (Jani et al. 2014 ). Altern Integ Med 2014 Volume 3, Issue 3 ISSN: 2327-5162, AIM an open access journal Traditional Medicine-014 August 25-26, 2014 August 25-26, 2014 DoubleTree by Hilton Beijing, China 2nd International Conference and Exhibition on Traditional Alternative Medicine Formulation, stability studies and analysis of new ayurvedic health supplement for ... CPCSEA has been very actively rescuing animals from laboratories. It has also enforced good laboratory practice related to animals, designed guidelines for the use of animals in the laboratories abiding by the principles of 3 R's and most importantly brought forward the concept CPCSEA Guidelines - Free download as PDF File (.pdf), Text File (.txt) or read online for free.
Organizer of workshop on Implementation of CPCSEA Guidelines in Pharmacy Institutions “Sponsored by ICMR, New Delhi” on 30 September & 1 October 2016 at Institute of Pharmaceutical Research, GLA University, Mathura, U.P., India. CPCSEA GUIDELINES TO CONDUCT EXPERIMENTS ON ANIMALS Presented by:- Lingaraj .V. Anawal M.Pharm Department of Pharmacology H.S.K College of Pharmacy bgk 1 slide 2: CONTENTS • COMMON LABORATARY ANIMALS • WHAT IS CPCSEA • FUNCTION OF CPCSEA • IAEC • COMPOSITION AND FUNCTION OF IAEC • GLP • GOAL • GUIDELINES • CONCLUSION ... To follow CPCSEA guidelines. To produce specific pathogen free (SPF) to germ free laboratory animals in this in vivo laboratory (Animal house) Capacity of Animal Breeding/Holding Rooms. ... 11.07.2014: Service/Utility. Service floor for housing Air Handling Units of the HVAC System. followed the guidelines of the institutional Animal Ethical Committee given by the Committee for Control and Supervision of Experiments on Animals (CPCSEA). Induction of experimental animals Cadmium was induced in groups II, III and IV. Briefly, Cadmium dissolved in distilled water was given by intra- June - July, 2014, Vol. 3, No.4, pp 1080-1084 ISSN: 2278-0238 Research Article EVALUATION OF ROLE OF ATORVASTATIN IN CISPLATIN INDUCED NEPHROTOXICITY IN WISTAR RATS Sravan Kumar Boorla 1, Sabitha Panchagiri2, Kiran Kumar Shastrala , Raja Bonagiri1 and Mohan Vangala3. 1. Supervision of Experiments on Animals (CPCSEA) guidelines and the experimental protocol was approved by the Institutional Local Animal Ethical Committee. The microbial cultures of gram positive bacteria B. subtillis (NCIM 2063), gram negative bacteria … the care of laboratory animals of IAEC (No.773/03/ac/CPCSEA/ FVSc, AAU/IEC/06/22). Effort was made to minimize suffering of the experimental animals throughout the study. Plant material and extract preparation Voucher specimens (IC Barua, 4915) were prepared by following the guidelines of Botanical Survey of India, poisoned with
an animal hold area, as per CPCSEA Guidelines is required. *As per the terms of Notification published on 19.03.2014 in the Gazette of India. A.1.10 *Central Incineration Plant An incinerator Plant commensurate with hospital bed strength may be provided. Alternatively any other system approved by the respective State Pollution Control AJPCT1081-1092 Acute toxicity studies The methanolic extract of Trigonella foenum graecum whole plant was tested for acute toxicity studies as per procedure given in OECD guidelines 425 and limit test method was followed. Mice were starved for 4h and fed orally with MeOH extract of Trigonella foenum 02/(i)/a/CPCSEA/ IAEC/ SVU/ KY-KK/ Dt. 21-03-2011. 2.3 Collection and preparation of Bacopa monniera plant extract: Bacopa monniera plant was collected from Talacona and identified by the Botanist, Department of Botany, S.V. University, Tirupati, India. The whole plant was dried in shade, powdered and used for extraction by using solvent.
ments on Animals (CPCSEA) guidelines for laboratory animal facility published in the gazette of India, December 15th 1998 (CPCSEA, 1998). Standard safety precau-tions were observed during the course of study. The study protocol (BIO-IAEC-219-10/04) was approved by the Institutional Animal Ethics Committee (IAEC) on 10th April 2010. 2.1.2. Test item Experiments on Animals (CPCSEA) guidelines. Synthesis and characterization of MRGO Moderately halophilic bacterium, (ATCC Halomonasmaura 700995) was purchased from ATCC and was propagated in MY medium as mentioned elsewhere [18,19].The medium was supplemented with various concentrations of graphene oxide (GO) for bacterial reduction. CPCSEA - statutory body - right to prohibit & regulate dissection. UGC bans dissection and animal experimentation in UG & PG vide notification dated July, 2014 Blue Cross of India –Developed Compu frog, Compu Pigeon, Compu Rat. “Ethical Guidelines for Biomedical Research on Human Participants" in 2006 , and ICMR is assisting Department of Health Research, MOH&FW in the process of its enactment as a Bill. The Indian National Science Academy (INSA) guidelines for Care and Use of Animals in Scientific Research (2000) and the Approved guidelines by CPCSEA on mal house and followed the guidelines given by the Committee for the Purpose of Supervision and Control of Experiments on Animals (CPCSEA), India. The research protocol was approved by the Institute animal ethical commit-tee (1220/a/08/CPCSEA/ANCP). DOX-induced myocardial necrosis A total of 30 healthy rats were divided into 5 dif- maintained according to the guidelines recommended by CPCSEA, New Delhi, India and approved by the Institutional Animal Ethics Committee (Approval number- JU-Dey’s/IAEC/09/14, dated 31.01.2014). Acute toxicity study Single-dose intraperitoneal toxicity study was con-ducted to determine the possible acute toxicity of surface-modified Mn 3 O 4 The reduced sperm count after arsenite administration was significantly (p<0.001) increased in Co-enzyme Q10 (10 mg kg-1) treated rats as compared to arsenic control rats ().. Effect of naringin and Co-enzyme Q10 on serum protein, albumin, AST and ALT in male rats: There was significant (p<0.001) decrease in serum protein, albumin, AST and ALT level in arsenic control animals as compared to ...
Committee (IITK/IAEC/2014/1023 and IITK/IAEC/ 2014/1022, respectively) of IIT Kanpur, under the Com-mittee for the Purpose of Control and Supervision of Ex-periments on Animals (CPCSEA), Government of India. All methods were performed in accordance with relevant guidelines and regulations of this committee. The ani- The developmental programme of epithelial-mesenchymal transition (EMT), involving loss of epithelial and acquisition of mesenchymal properties, plays an important role in the invasion-metastasis cascade of cancer cells. In the present study, we show that activation of AMP-activated protein kinase (AMPK) using A769662 led to a concomitant induction of EMT in multiple cancer cell types, as ... guidelines for animal protection and welfare bearing the CPCSEA 438/01/a/cpcsea/dt 17.07.2001 in its resolution No: 9/IAEC/SVU/SK/2009/dt 14.03.2009. Selection of Pesticide Deltamethrin, a synthetic pyrethroid pesticide, was selected for the present study. It was obtained as commercial grade chemical from Sigma chemicals, USA. per the requirement and guidelines of the Committee for the Purpose of Control and Supervision of Experiments on Animals (CPCSEA), Government of India, and after obtaining permission of the Institutional Animal Ethics Committee (IAEC). 690 MOLECULAR ONCOLOGY 9 (2015) 689e703 2014-15 Date 17/10/2014) and conducted according to CPCSEA guidelines, Govt. of India. Acute Oral Toxicity Study11 Albino mice of either sex weighing 25-30 g selected by random sampling technique was performed as per OECD-423 guidelines. The animals were fasted for 3-4 hr, provided only Revised ICH (International Conference on Hormonisation) Quality Guidelines in pharmaceuticals are given below: Q1A (R2) – Stability Testing of New Drug Substances and Products Q1 B – Stability Testing : Photo Stability Testing of New Drug Substances and Products Q1C – Stability Testing for New Dosage Forms Q1D – Bracketing and Matrixing Designs for Stability Testing of New Drug ...
Research Article Anti-Inflammatory and Antiarthritic Activity of Anthraquinone Derivatives in Rodents AjayD.Kshirsagar, 1 PrashantV.Panchal, 2 UdayN.Harle, 2 RabindraK.Nanda, 2 andHaidaraliM.Shaikh 2 School of Pharmacy, Swami Ramanand Teerth Marathwada University, Vishnupuri, Nanded, Maharashtra , India guidelines provided in IS 4011 . Animal tests used for cosmetics ... Standard in 2007 •In February,2014, the IS 4011 was amended specifying that when there is a need for safety evaluation of cosmetic products to demonstrate absence of oral toxicity and/or oral mucosal ... (CPCSEA) to People for the Ethical Treatment of Animals (PETA), through ... supervision of experiments on animals (CPCSEA) guidelines for ethical use of animals (CPCA no. 158/99/CPCSEA/14/ 2011). Preselection of animals The rota-rod test was performed to investigate the motor coordination of the mice. Mice were placed on a rotating rod (10rpm) and the latency to falling was measured for up to an animal hold area, as per CPCSEA Guidelines is required. *As per the terms of Notification published on 19.03.2014 in the Gazette of India. A.1.10 *Central Incineration Plant An incinerator Plant commensurate with hospital bed strength may be provided. Vimal Kumar Varun Scientist ‘F’ and Member Secretary (ITeG) Room No. 14-B, S&T Block I Department of Scientific & Industrial Research (DSIR) Technology Bhawan, New Mehrauli Road Guidelines for Animal Disease Control 1. Introduction and objectives The guidelines are intended to help countries identify priorities, objectives and the desired goal of disease control programmes. Disease control programmes are often established with the aim of eventual eradication of agents at a country, zone or compartment level. 4. Ethical Guidelines for Biomedical Research on Human Participants by Indian Council of Medical Research New Delhi 2006. 5. CPCSEA Guidelines for Laboratory Animal Facility by Committee for the purpose of control and supervision on experiments on animals (CPCSEA) 6. (IAEC/KMC/03/2014) and experiments were conducted according to the ethical norms approved by Ministry of Social Justices and Empowerment (Government of India), Committee for the Purpose of Control and Supervision on Experiments on Animals (CPCSEA) guidelines. Drugs Nicotinamide 2%, 3%, 4% gel was obtained from